Volume: 45

 Issue: 3
 Pages: 357-363

DOI: 10.1016/j.jcms.2017.01.006

Published: MAR 2017


We hypothesized that local infection plays a critical role in the pathogenesis of medication-related osteonecrosis of the jaw (MRONJ). Recent developments in molecular methods have revolutionized new approaches for the rapid detection of microorganisms including those difficult to culture. The aim of our study is to identify the bacterial profiles in MRONJ by microbiological culture and polymerase chain reactions (PCR). A retrospective analysis was performed on MRONJ patients from 2008 to 2014. The bacterial profile from MRONJ bone samples was determined using microbiological culture and PCR. Ninety five patients fulfilled the inclusion criteria with mean age of 69.85 +/- 8.71 years. A female predilection was detected. The mandible was more commonly affected than maxilla. Tooth extraction was the frequent triggering factor. Breast cancer was the primary cause for administration and intravenous bisphosphonates were the most commonly administrated antiresorptive drugs. The majority of patients were classified as stage 2. Posterior teeth were most commonly affected. Based on bone culture results, the most common microorganism were both actinomyces and mixed flora. PCR confirmed the presence of actinomyces in 55 patients. Our data suggest that PCR might be an innovative method for detection of microorganisms difficult to culture using traditional microbiological techniques. (C) 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Author Information

Reprint Address: Otto, S (reprint author)

Categories / Classification

Research Areas:Dentistry, Oral Surgery & Medicine; Surgery

Web of Science Categories:Dentistry, Oral Surgery & Medicine; Surgery

Document Information

Document Type:Article


Accession Number: WOS:000397073700001

PubMed ID: 28162845

ISSN: 1010-5182

eISSN: 1878-4119

Other Information

IDS Number: EP0JN

Cited References in Web of Science Core Collection: 50

Times Cited in Web of Science Core Collection: 0